| 中文名称 |
GMQ hydrochloride |
| 英文名称 |
GMQ hydrochloride |
| 英文别名 |
GMQ hydrochloride;1-(4-Methyl-2-quinazolinyl)guanidine hydrochloride (1:1);2-Guanidine-4-methylquinazoline hydrochloride;4-Methyl-2-guanidino quinazoline hydrochloride;N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride;NSC 403387 hydrochloride |
| CAS No. |
5361-15-9 |
| 分子式 |
C10H12ClN5 |
| 分子量 |
237.69 |
| 纯度 |
≥95% (HPLC) |
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生化/生理作用
GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.
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