| 中文名称 |
V-9302 |
| 英文名称 |
V-9302 |
| 英文别名 |
(S)-2-amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid;s8818;ZB1562;BDBM50140122;(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid;V-9302;HY-112683;G60987;CS-0062616;CHEMBL3754053;V-9302?;AKOS040758738;SCHEMBL26092192;AS-84793;(S)-2-Amino-4-(bis(2-((3- methylbenzyl)oxy)benzyl)amino)butanoic acid;AC-35594;(2S)-2-amino-4-[bis({2-[(3-methylphenyl)methoxy]phenyl}methyl)amino]butanoic acid;EX-A2965;1855871-76-9;(2S)-2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]-butanoic acid |
| CAS No. |
1855871-76-9 |
| 分子式 |
C34H38N2O4 |
| 分子量 |
538.68 |
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说明
Biochem/physiol Actions
Competitive antagonist of the amino acid transporter ASCT2 (SLC1A5) with anti-tumor activity
V-9302 is a selective competitive antagonist of the amino acid transporter ASCT2 (SLC1A5) with anti-tumor activity. V-9302 caused reduced cellular viability and increased cell death in a panel of cancer cell lines and reduced tumor cell growth in both HCT-116 and HT29 (Fig. 5f) xenograft models.
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