一般描述

A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

生化/生理作用

Cell permeable: no

ED50 = 15 µM against COX-1

Primary Target

COX-1

Product does not compete with ATP.

Reversible: no

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Howitz, K.T., et al. 2003. Nature425, 191.

Lin, H.Y., et al. 2002. J. Urol.168, 748.

Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.

Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.

Jang, M., et al. 1997. Science 275, 218.

Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.